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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mifepristone
supplement:
Progesterone
Research Papers that Mention the Interaction
“When mifepristone was administered in the early luteal phase, downregulation of progesterone receptors was inhibited in five of six women.”
Emergency Contraception With Mifepristone and Levonorgestrel: Mechanism of Action“High-dose LD and mifepristone lowered serum levels of estradiol, progesterone and LH (P < 0.05).”
“In fact adding progesterone to the culture media upregulated PIBF protein expression and mifepristone inhibited it.”
“On the contrary, the effect of a combination of mifepristone with progesterone or hydrocortisone on the increase in DNA fragmentation, bcl(2) downregulation, and induction of TGFbeta(1) protein was additive and significantly different (P < 0.05) from the effect of mifepristone monotherapy.”
“The progesterone antagonists ZK98299 (Onapristone) and RU 486 ( Mifepristone ) inhibit the transcriptional activity of PR by complex mechanisms at concentrations much lower than the progestins.”
“While estrogen leads to increased production of PGF2alpha, progesterone stimulates the production of prostacyclin synthase, Mifepristone , which blocks progesterone at the receptor level, increases uterine activity and sensitivity to PG.”
“The synthesis of mifepristone , an antiprogestin blocking the action of progesterone at the receptor level, started a new era of medical termination of pregnancy (MTOP).”
“ Progesterone use to reverse the effects of mifepristone.”
“This study demonstrated that mifepristone blockage of progesterone receptors was reversible, and that progesterone rescue could block the abortifacient effect of mifepristone if given soon after mifepristone dosing.”
“One published case series detailed a potential method to counter/reverse the abortifacient effect of mifepristone by administering parenteral progesterone in such situations.”
“ Progesterone use in early pregnancy is low risk and its application to counter the effects of mifepristone in such circumstances may be clinically beneficial in preserving her threatened pregnancy.”
“ Mifepristone (RU486) blocked the immunosuppressive effect of progesterone.”
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