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Last Updated: 3 months ago

Possible Interaction: Mifepristone and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

We hypothesise that inhibition of glucocorticoid receptor by mifepristone resulted in an increase in adrenocorticotropic hormone and subsequent increase in adrenal androgens, and that their conversion by tumour cells to testosterone and DHT probably limited the efficacy of mifepristone.
BJU international  •  2008  |  View Paper
Mifepriston caused a large rise in plasma ACTH levels during the morning hours in comparison to untreated male control subjects.
Plasma ACTH levels in the Mifepriston treated subject at 7.00 h were threefold greater than in the control subjects (104.4 pg/ml vs. 37.6±13.9 pg/ml; $$\bar x$$ ±SD).
European Archives of Psychiatry and Clinical Neuroscience  •  2005  |  View Paper
The GR antagonist, mifepristone , interfered with negative feedback on both ACTH burst mass and secretion regularity.
The Journal of clinical endocrinology and metabolism  •  2016  |  View Paper
In addition, mifepristone significantly elevated cortisol and ACTH levels and steepened ascending slopes from 1800 to 0100 and from 0100 to 0900 as compared to placebo.
Neuropsychopharmacology  •  2006  |  View Paper
Administration of Mif increased the morning plasma ACTH and cortisol surges, whereas Meg had the opposite effect.
The American journal of physiology  •  1998  |  View Paper
Administration of Mif increased the morning plasma ACTH and cortisol surges, whereas Meg had the opposite effect.
American journal of physiology. Endocrinology and metabolism  •  1998  |  View Paper
A marked reduction in cortisol production following adrenocorticotropic hormone stimulation of head kidney pieces was observed from mifepristone treated fish.
General and comparative endocrinology  •  2012  |  View Paper
In addition, mifepristone dampened the ACTH response to FST exposure.
Psychoneuroendocrinology  •  2010  |  View Paper