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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mifepristone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Mifepriston caused a large rise in plasma ACTH levels during the morning hours in comparison to untreated male control subjects.”
“Plasma ACTH levels in the Mifepriston treated subject at 7.00 h were threefold greater than in the control subjects (104.4 pg/ml vs. 37.6±13.9 pg/ml; $$\bar x$$ ±SD).”
Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern“In addition, mifepristone significantly elevated cortisol and ACTH levels and steepened ascending slopes from 1800 to 0100 and from 0100 to 0900 as compared to placebo.”
“A marked reduction in cortisol production following adrenocorticotropic hormone stimulation of head kidney pieces was observed from mifepristone treated fish.”
Central and peripheral glucocorticoid receptors are involved in the plasma cortisol response to an acute stressor in rainbow trout.“In addition, mifepristone dampened the ACTH response to FST exposure.”
“Results: Mean serum cortisol and adrenocorticotropic hormone levels increased dose dependently with mifepristone treatment.”
Evaluation of Evidence of Adrenal Insufficiency in Trials of Normocortisolemic Patients Treated With Mifepristone“ Mifepristone treatment was associated with acute increases in cortisol and ACTH levels and decreases in cytosolic glucocorticoid receptor number in lymphocytes.”
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