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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Midazolam and Serum Albumin, Human

Research Papers that Mention the Interaction

Compared with control, addition of HSA resulted in a 91% decrease in the peak intracellular midazolam level and a 86% decrease in the rate of 1'-hydroxylation after the administration of midazolam into basolateral medium.
Inclusion of HSA in the basolateral medium decreased peak intracellular midazolam accumulation after an apical midazolam dose (3 microM) by 35% and reduced the 1'-hydroxymidazolam formation rate by approximately 20%.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper