“In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam , and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.”
“… quercetin … midazolam (160.88 ± 45.58 ng·h/mL vs 188.07 ± 65.75 ng·h/mL, P < .05), significantly decreased the AUC0‐∞ of midazolam (165.… ± 0.89 h, P < .01), and decreased tmax significantly (0.48 ± 0.36 h vs 1.06 ± 0.69 h, P < .01), respectively.”