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Last Updated: 2 years ago

Possible Interaction: Midazolam and Quercetin

supplement:

Quercetin

Research Papers that Mention the Interaction

In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam , and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.
quercetin … midazolam (160.88 ± 45.58 ng·h/mL vs 188.07 ± 65.75 ng·h/mL, P < .05), significantly decreased the AUC0‐∞ of midazolam (165.… ± 0.89 h, P < .01), and decreased tmax significantly (0.48 ± 0.36 h vs 1.06 ± 0.69 h, P < .01), respectively.
Journal of clinical pharmacology  •  2012  |  View Paper
Coadministration with a single dose of quercetin … its 1'-hydroxymetabolite, but following short-term quercetin … midazolam exposure (geometric mean ratio of test-control area under the plasma concentration-time curve (AUC0-∞ ): 0.82; … midazolam-metabolite AUC0-∞ ratios were decreased by 9.7%-47.6% from control in seven subjects.
Journal of pharmaceutical sciences  •  2015  |  View Paper