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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Midazolam
supplement:
Kaempferol
Research Papers that Mention the Interaction
“Whereas flavones possessing more than two hydroxyl groups luteolin , diosmetin) inhibited MDZ biotransformation, flavones lacking hydroxyl groups in their A and B rings (flavone, tangeretin) stimulated MDZ metabolism.”
Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.
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