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Last Updated: 3 years ago

Possible Interaction: Midazolam and Green Tea Extract

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drug:

Midazolam

supplement:

Green Tea Extract

Research Papers that Mention the Interaction

“These studies indicate that subchronic ingestion of GTE or GSE may alter the pharmacokinetics of MDZ , and the effects of GTE on CYP3A activity appear opposite between liver and small intestine, which could not be predicted from in vitro experiments.”

Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam.

Drug metabolism and pharmacokinetics • 2004 | View Paper

“In RHM, GTE inhibited MDZ 1'-hydroxylation with IC₅₀ and K(i)(app) values of 12.5 and 18.8 µg/mL, respectively, in a noncompetitive manner.”

Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.

Drug metabolism and pharmacokinetics • 2013 | View Paper

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