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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Midazolam
supplement:
Berberine Hydrochloride
Research Papers that Mention the Interaction
“AbstractAim To evaluate whether berberine hydrochloride (BBR) could modify the pharmacokinetic profiles of midazolam (MDZ), a substrate of CYP3A, and rhodamine 123 (Rh123), a substrate of P-glycolprotein (P-gp), in male rats.”
“And BBR could significantly increase the peak plasma concentrations (Cmax) of MDZ (p < 0.01), but reduce the clearance rate (CLz) and the apparent volume of the distribution (Vz) of MDZ (p < 0.05).”
Effects of berberine on pharmacokinetics of midazolam and rhodamine 123 in rats in vivo
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