Possible Interaction: Miconazole and Progesterone

“In the H295R cell assay, the conazoles decreased the formation of estradiol and testosterone, and increased the concentration of progesterone , indicating inhibition of enzymes involved in the conversion of progesterone to testosterone.”

“Using the GFP‐reporter strain, we show CDR1 induction by female but not male human serum and demonstrate that exposure of C. albicans to physiological concentrations of progesterone measurably increases resistance to fluconazole, miconazole and 5‐fluorouracil.”

“Finally, the concentration of progesterone was strongly enhanced with high doses of miconazole , whereas etomidate suppressed progesterone production.”