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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mibefradil
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“They also observed that mibefradil reduced the surface expression of β2 integrins and L-selectin and inhibited the fMLP induced calcium rise, indicating that mibefradil interferes with the integrin signaling through blocking the intracellular Ca2+ rise.”
Impaired Mechanisms of Leukocyte Adhesion In Vitro by the Calcium Channel Antagonist Mibefradil“The Ca2+ signals evoked by alkaline pH and progesterone are inhibited by the Cav channel blockers NNC 55-0396 and mibefradil.”
“ Mibefradil was able to significantly inhibit the formyl-methionyl-leucyl-phenylalanine (fMLP) induced calcium rise, which suggests that mibefradil interfered with integrin signaling through blocking the intracellular calcium rise.”
“ Mibefradil inhibited Ca2+‐activated Cl− currents, ICl, Ca , activated by loading CPAE cells via the patch pipette with 500 nM free Ca2+ (Ki=4.7±0.18 μM, n=8).”
Inhibition by mibefradil, a novel calcium channel antagonist, of Ca2+‐ and volume‐activated Cl− channels in macrovascular endothelial cells“ Mibefradil is a new calcium antagonist that can inhibit cardiac calcium current without reducing myocardial force development.”
“A panel of various OR ligands induced Ca2+ signals in human spermatozoa, which could be inhibited by mibefradil.”
Characterization of the Olfactory Receptors Expressed in Human Spermatozoa
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