Possible Interaction: Metyrapone and Progesterone

“An inhibitor of 11beta-hydroxylase activity metyrapone ; 0.1 mM) effectively eliminated the inhibition of prostaglandin biosynthesis caused by corticotropin and progesterone.”

“Moreover, progesterone , the corticosterone precursor, also stimulated GH mRNA expression in the cultured chicken pituitary gland, and this effect was blocked by pretreatment with metyrapone.”

“ Progesterone 16 alpha-hydroxylase is also inhibited by metyrapone. (”

“A single injection into laying hens of 60 mg metyrapone 28 h after the final ovulation of a sequence induced increases in the plasma concentrations of LH and progesterone , followed by premature ovulation.”

“ Metyrapone totally prevented the accumulation of radioactivity in the bronchial epithelium and progesterone reduced this accumulation; the other substances used for pretreatment had no effect on the uptake of radioactivity.”

“After a 1-hr incubation of the adrenal glands of fetuses injected with Metopirone , hydroxylation of progesterone into corticosterone (B), 18-hydroxycorticosterone (18-OH-B) and 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) decreased and the synthesis of 11-deoxycorticosterone increased.”

“Following preincubation of the fetal adrenal glands and 1-hr incubation with Metopirone , hydroxylation of progesterone into DOC increased and the synthesis of B decreased.”