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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metyrapone
supplement:
Progesterone
Research Papers that Mention the Interaction
“An inhibitor of 11beta-hydroxylase activity metyrapone ; 0.1 mM) effectively eliminated the inhibition of prostaglandin biosynthesis caused by corticotropin and progesterone.”
Prostaglandin biosynthesis in the human fetal adrenal gland: regulation by glucocorticosteroids.“Moreover, progesterone , the corticosterone precursor, also stimulated GH mRNA expression in the cultured chicken pituitary gland, and this effect was blocked by pretreatment with metyrapone.”
Hypophyseal corticosteroids stimulate somatotrope differentiation in the embryonic chicken pituitary gland“ Progesterone 16 alpha-hydroxylase is also inhibited by metyrapone. (”
“A single injection into laying hens of 60 mg metyrapone 28 h after the final ovulation of a sequence induced increases in the plasma concentrations of LH and progesterone , followed by premature ovulation.”
“ Metyrapone totally prevented the accumulation of radioactivity in the bronchial epithelium and progesterone reduced this accumulation; the other substances used for pretreatment had no effect on the uptake of radioactivity.”
“After a 1-hr incubation of the adrenal glands of fetuses injected with Metopirone , hydroxylation of progesterone into corticosterone (B), 18-hydroxycorticosterone (18-OH-B) and 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) decreased and the synthesis of 11-deoxycorticosterone increased.”
“Following preincubation of the fetal adrenal glands and 1-hr incubation with Metopirone , hydroxylation of progesterone into DOC increased and the synthesis of B decreased.”
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