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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Metyrapone
supplement:
Heme Iron
Research Papers that Mention the Interaction
“In addition to the direct coordination of metyrapone to the heme iron , the hydrogen bond interaction between the inhibitor carbonyl group and the side chain of Ser119 also contributes significantly to stabilizing the CYP3A4-metyrapone complex.”
Structural and dynamical basis of broad substrate specificity, catalytic mechanism, and inhibition of cytochrome P450 3A4.
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