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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Metyrapone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“As expected, CO2 increased measures of anxiety, and metyrapone lowered cortisol and increased ACTH levels.”
Effects of the cortisol synthesis inhibitor metyrapone on the response to carbon dioxide challenge in panic disorder“The plasma concentrations of corticotropin and deoxycortisol were significantly higher during metyrapone treatment (multivariate analysis of covariance, P<.05), whereas cortisol remained largely unchanged.”
“ Metyrapone markedly increased basal ACTH (294.4 ± 61.6 pg/ml, p < 0.05), reduced basal cortisol (19.6 ± 7.2 µg/l, p < 0.05), while it did not modify GH levels.”
“ MET administration disproportionately increased the ACTH response to NAL, producing a significant increase (P < 0.01) in the slope of the regression relating ACTH responses to CRH and NAL.”
“The adrenal synthesis of cortisol was inhibited by metyrapone which caused a prompt increase in the plasma concentration of ACTH and 11-deoxycortisol.”
“However, even when pituitary tumors occur, ACTH levels can be altered by metyrapone , dexamethasone and LVP.”
“ Metyrapone produced marked increases in plasma ACTH within 24 hr in all cases and generally within 3-6 hr except when started late in the day.”
“ Metyrapone was used to suppress cortisol production and resulted in decreased levels of ACTH and cortisol.”
“Daily metyrapone therapy decreased her plasma cortisol and ACTH levels during every hypercortisolemic phase.”
“ Metyrapone resulted in a greater increase in ACTH and greater decreases in cortisol and delta spectral power sleep in PTSD subjects compared to controls, and a greater increase in ACTH in women compared to men.”
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