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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Metronidazole
supplement:
Silymarin
Research Papers that Mention the Interaction
“Administration of silymarin increased the clearence of metronidazole and its major metabolite, hydroxy-metronidazole (HM) by 29.51% and 31.90%, respectively, with a concomitant decrease in half-life, Cmax and AUC(0-48).”
Study on the influence of silymarin pretreatment on metabolism and disposition of metronidazole.“Seven days after treatment, the efficacy of silymarin plus metronidazole was found 79%, whereas that of metronidazole was 72%.”
“Ten days post-treatment the efficacy of metronidazole plus silymarin (91%) was significantly different in comparison with that of metronidazole (75%).”
“There were significant differences of body weight between the dogs treated with silymarin and metronidazole.”
Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs
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