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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Metoprolol
supplement:
Quinidine
Research Papers that Mention the Interaction
“In addition, when metoprolol was the substrate, inhibitors with structurally constrained amino moieties (clozapine, debrisoquine, harmine, quinidine , and yohimbine) exhibited at least a 5-fold decrease in inhibition potency when results were compared with those for dextromethorphan.”
Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition“The inhibition of metoprolol metabolism by quinidine (Qd) was 200 times more potent than that of quinine (Qn), both for alpha-hydroxylation (Qd IC50 = 0.05 microM; Qn IC50 = 4 microM) and O-demethylation (Qd IC50 = 0.05 microM; Qn IC50 = 4 microM).”
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