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“Pharmacological blockade of β-adrenergic receptors with metoprolol decreased the heart rate in all genotypes, but the extent of the decrease was most obvious in Ca <sub>V</sub>β<sub>3</sub>-Tg mice.”
“Under voltage-clamp conditions, metoprolol blocked the high threshold calcium current at concentrations of 30 and 100 mumol/l to 82 +/- 4% and 73 +/- 5% from control, respectively.”