Possible Interaction: Metoclopramide and Adrenocorticotropic Hormone

“ Metoclopramide significantly decreased plasma gastrin‐ and suppressed ACTH‐IS and cortisol levels compared with the placebo.”

“Administration of MTC , compared to saline, caused a moderate (not significant) plasma ACTH increase, and a significant cortisol increase (p < 0.05), both in hyperprolactinemic and normal subjects, without statistically significant differences between the two group.”

“ ACTH and cortisol rose by 45 and 55%, respectively, in response to MCP.”

“Since MCP significantly increased also ACTH levels we cannot exclude an involvement of this hormone on MCP-induced ALD release.”

“ Metoclopramide may stimulate ACTH secretion by decreasing dopaminergic inhibition of ACTH release.”

“OBJECTIVE A dopamine (DA) antagonist, metoclopramide , stimulates ACTH secretion in some women with hypothalamic amenorrhoea (HA) but not in normal women.”

“ MCP may stimulate ACTH release through an antidopaminergic mechanism, and endogenous dopaminergic tone is likely to be increased during the luteal phase compared to the follicular phase.”

“Within 15 min after metoclopramide administration, plasma aldosterone (+ 99%), cortisol (+ 75%) and ACTH (+ 55%) increased (p less than 0.001), whereas the plasma levels of these hormones were not altered after domperidone.”

“After injecting 20 mg metoclopramide , the ACTH level increased significantly from 20 min to 60 min and the cortisol level showed a significant increase from 20 min to 120 min.”