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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methysergide
supplement:
Tryptophan
Research Papers that Mention the Interaction
“The obstructive apnoeas liable … occur after an L‐tryptophan load (50 mg kg‐1) were prevented … blocking the 5‐HT receptor with methysergide (50 mg kg‐1, n = 5) or by blocking the 5‐HT biosynthesis … applying p‐chlorophenylalanine (PCPA) pretreatment at birth (300 mg kg‐1, n = 7).”
Changes in serotonin metabolism may elicit obstructive apnoea in the newborn rat.“Further results described support this hypothesis, particularly the fact that the specific anti-serotonin agent, methysergide , prevented the effect of tryptophan.”
“On days 3, 5 and 7 high doses of L-tryptophan elicited an increase of FS, while high doses of methysergide caused significant impairment of performance.”
The role of dopaminergic and serotonergic mechanisms in the development of swimming ability of young rats.
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