“Altogether, our study demonstrated ZA can prevent the tumor-promoting effects of MSC.”
“Furthermore, it was found that ZA decreased MCP-1 expression of MSC , and therefore reduced the recruitment of TAMs to the tumor sites and hence inhibited the tumor growth.”
“In addition, our data revealed that ZA weakened the ability of MSC to promote tumor growth by impairing TAMs recruitment and tumor vascularization.”
“The antitumor effects of ZA were caused by decreasing the MCP-1 expression of MSC , which further decreased the infiltration of TAMs into tumor sites, and therefore inhibited the tumor growth.”