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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Methylselenocysteine
drug:
Cpt-11
Research Papers that Mention the Interaction
“ Methylselenocysteine (MSC, 0.2 mg/mouse per day per oral for 35 days starting 7 days before the first irinotecan (CPT-11)) has been found to increase efficacy of a wide variety of chemotherapeutic agents including CPT-11 (100 mg/kg per week x 4 intravenously).”
“Whereas CPT-11 leads to a 10% complete response (CR) in A253 xenografts, the combination of MSC and CPT-11 increased the CR to 70%.”
Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts.“The combination of methylselenocysteine and irinotecan ( CPT-11 ) is synergistic against FaDu and A253 xenografts.”
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