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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methylprednisolone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Patients treated with methylprednisolone had progressive and sustained reductions of TNF-alpha, IL-1beta, IL-6, ACTH , and cortisol concentrations over time.”
Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids.“It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months.”
“Furthermore there was a good correlation between percentage changes in ACTH and BLI following MP in group B (r = .87, P less than .01) but not in group A. Possible explanations for these findings are discussed.”
“ Methylprednisolone suppressed ACTH stress responses although AM251 still delayed restoration of ACTH levels to the baseline.”
Participation of endocannabinoids in rapid suppression of stress responses by glucocorticoids in neonates“Significant (P < 0.05) suppression of cortisol and a trend toward suppression of ACTH was observed after 1 week of MP administration.”
“Consequently, a difference between daily- and alternate-day MP administration was detected after ACTH challenge exposure; MPA administration inhibited adrenal cortisol secretion for at least the duration of the experiment.”
“Dogs given MP daily had a depressed response to ACTH.”
“In response to ACTH , cortisol values invariably increased sharply in nontreated control dogs and in those dogs given MP on an alternate-day basis.”
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