Possible Interaction: Methylene Blue and Vitamin C

“Oral pretreatment with the cyclooxygenase inhibitor acetylsalicylic acid or local coinfusion of ascorbic acid and the nitric oxide synthase inhibitor NG-monomethyl-l-arginine had no effect, but coinfusion of ascorbic acid and methylene blue (to inhibit cGMP generation) abolished venodilation.”

“He responded to a low dose of methylene blue along with intravenous vitamin C and the level of fMetHb came down to 20% within 1 hour.”

“Inhibition of the ascorbic acid-induced lipid peroxidation in cultured human fibroblasts with alpha-tocopherol (50 mumol/L) or methylene blue (10 mumol/L) prevented the stimulation of collagen gene expression.”

“Inhibition of the ascorbic acid-induced lipid peroxidation in cultured human fibroblasts with alpha-tocopherol (50 microM) or methylene blue (10 microM) prevented the stimulation of collagen gene expression.”

“We have found that methylene blue alone caused a significant drop in hypophyseal both AA and plasma AA concentrations.”

“ Methylene blue also inhibited the response to ascorbic acid in the intact vessels precontracted with high K+.”

“ Methylene blue , but not propranolol, blocked the endothelial augmentation of vascular relaxation to ascorbic acid.”

“However, at higher dose levels, MB masked the preventive effect of ASA on SHb-emia.”

“Finally, ascorbic acid in the electrolyte was utilized to reduce the oxidation of MB and improve the electrochemical signal of MB electro-oxidation.”

“The oxidation of MB can be reduced by ascorbic acid.”

“MB concentration was decreased as a function of decreasing fluorescence intensity due to forming colorless form of MB (Leuco-MB) in the reaction between AA and MB.”