“… methyldopa has been associated … sFlt1 and sEng in women with pre-eclampsia (PE), and direct effects on placental vascularisation have been reported for some pregnancyrelated antihypertensives such as … sFlt-1 concentration in the medium, and methyldopa can increase VEGF concentration, whereas labetalol increases trophoblast integration without decreasing sFlt-1.”