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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methyldopa
supplement:
Ferrous Sulfate
Research Papers that Mention the Interaction
“… ferrous sulfate … methyldopa there was a decrease in the proportion of methyldopa excreted as “free” methyldopa (49.5% ± 12.4% vs 21.1% ± 4.77%; p < …< 0.01), and a decrease in the percentage of methyldopa absorbed (29.1% ± 12.5% vs 7.88% ± 4.14%; p< 0.01).”
Alteration of methyldopa absorption, metabolism, and blood pressure control caused by ferrous sulfate and ferrous gluconate“The findings suggest that care should be exercised when simultaneous administration of either methyldopa or levodopa with ferrous sulphate is indicated.”
“ Ferrous sulfate and sodium sulfate reduce methyldopa absorption in humans.”
“ Ferrous sulfate reduced methyldopa absorption 52.9% (p less than 0.01), while sodium sulfate had no significant effect on methyldopa absorption.”
Ferrous sulfate reduces methyldopa absorption: methyldopa: iron complex formation as a likely mechanism.“No ADR was caused by drug-drug interaction; however, a significant increase in blood pressure was observed in all patients using concurrent methyldopa and ferrous sulfate.”
Adverse drug reactions in high-risk pregnant women: A prospective study
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