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“In a cell line, stably expressing α1A-adrenoceptors fused to the mCherry red fluorescent protein, noradrenaline, methoxamine , and oxymetazoline induced concentration-dependent increases in intracellular calcium.”
European journal of pharmacology • 2020 | View Paper
“The pressor effect of methoxamine was noticeably less after both of the increases in ionic plasma calcium , and the pressor effect of B-HT 920 was also significantly reduced when the increase in calcium levels was more marked.”
“The calcium entry blocking agent also reduced pulmonary vasoconstrictor responses to methoxamine and to BHT 933, alpha 1- and alpha 2-adrenoceptor agonists, and to U 46619, an agent which mimics the actions of thromboxane A2.”
“During the plateau phase of the methoxamine response , a stepwise increase in the concentration of calcium from 1.6 to 20.1 mM (2 mM increments) elicited dose-dependent decreases in the level of contraction (relaxation).”
“The initial rate of force development in response to methoxamine was decreased by elevations in the extracellular concentration of calcium from 1.6 to 20.1 mM. D-600 antagonized this inhibitory effect of elevated calcium on the rate of force development.”