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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methoxamine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In a double-blind study in normal subjects, methoxamine , a highly selective agonist at alpha-1-adrenoceptors, significantly increased circulating ACTH and cortisol.”
Alpha-adrenergic stimulation of corticotropin secretion by a specific central mechanism in man.“ Methoxamine stimulated the secretion of ACTH in the normal, but not in the vasopressin-deficient, rats.”
Brattleboro rats have deficient adrenocorticotropin responses to activation of central alpha 1-adrenoceptors.“In conscious rats bearing venous and cerebroventricular cannulae, central administration of the alpha 1-adrenergic agonist methoxamine stimulated the secretion of ACTH , and the effect was reduced by the alpha 1-antagonist prazosin.”
“ Methoxamine was more potent in stimulating ACTH secretion when injected icv than peripherally, suggesting that the stimulant alpha 1-adrenoceptors are located in the brain rather than in the periphery.”
“Norepinephrine, epinephrine and clonidine, but not methoxamine and phenylephrine inhibited ACTH secretion.”
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