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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Methotrexate
supplement:
Vitamin E
Research Papers that Mention the Interaction
“Furthermore, high‑dose MTX enhanced α‑tocopherol succinate‑induced anticancer activity; however, low‑dose MTX inhibited α‑tocopherol succinate‑induced anticancer activity.”
“However, whether MTX plus vitamin E variants or its derivatives can inhibit TNBC remains unclear.”
“The results demonstrated that combination treatment with MTX and α‑tocopherol suppressed TNBC cell proliferation.”
Anticancer effects of methotrexate in combination with α‑tocopherol and α‑tocopherol succinate on triple‑negative breast cancer.“It could be concluded the biochemical, morphological, and morphometric findings suggested that vitamin E coadministration is promising in attenuating the placental toxic effect of methotrexate.”
Efficacy of vitamin E in protection against methotrexate induced placental injury in albino rats.“ Vitamin E also enhances the efficacy of Cyclophosphamide, Adriamycin and Methotrexate.”
“The uptake system is partially stabilized by including glucagon, hydrocortisone, and tocopherol in the medium; these factors increase both the rate and extent of accumulation of methotrexate and result in intracellular levels that are approximately 250% of control (4 h incubation) after 24 and 48 h in culture.”
“Co-administration of MTX and CMFE and/or Vit E resulted in protection from MTX-reduced TAOC.”
Protective effects of vitamin E and Cornus mas fruit extract on methotrexate-induced cytotoxicity in sperms of adult mice
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