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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Vitamin E


Vitamin E

Research Papers that Mention the Interaction

Furthermore, high‑dose MTX enhanced α‑tocopherol succinate‑induced anticancer activity; however, low‑dose MTX inhibited α‑tocopherol succinate‑induced anticancer activity.
However, whether MTX plus vitamin E variants or its derivatives can inhibit TNBC remains unclear.
The results demonstrated that combination treatment with MTX and α‑tocopherol suppressed TNBC cell proliferation.
Oncology reports  •  2019  |  View Paper
It could be concluded the biochemical, morphological, and morphometric findings suggested that vitamin E coadministration is promising in attenuating the placental toxic effect of methotrexate.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2021  |  View Paper
Vitamin E also enhances the efficacy of Cyclophosphamide, Adriamycin and Methotrexate.
In vivo  •  1988  |  View Paper
The uptake system is partially stabilized by including glucagon, hydrocortisone, and tocopherol in the medium; these factors increase both the rate and extent of accumulation of methotrexate and result in intracellular levels that are approximately 250% of control (4 h incubation) after 24 and 48 h in culture.
Archives of biochemistry and biophysics  •  1981  |  View Paper
Co-administration of MTX and CMFE and/or Vit E resulted in protection from MTX-reduced TAOC.
Veterinary research forum : an international quarterly journal  •  2014  |  View Paper