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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Vitamin D
Research Papers that Mention the Interaction
“A decrease in 25(OH)D3 levels during MTX therapy was observed in children with ALL that developed severe oral mucositis.”
A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia“Twins have multiple mutations: a CC mutation …>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of three SNPs in the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and … genotype in SNPs ATIC_rs2372536_347C>G, MTHFD1_rs2236225_1958G>A. These mutations are known to predict a worse outcome of MTX ….”
“Adding vitamin D supplementation to methotrexate may protect lipid homeostasis, specifically cholesterol and triglycerides.”
The impact of Methotrexate therapy with vitamin D supplementation on the cardiovascular risk factors among patients with psoriasis; A prospective randomized comparative study.
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