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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Vitamin C
Research Papers that Mention the Interaction
“However, combined low-dose vitamin C and MTX had synergistic anti-proliferative/cytotoxic effects on TNBC cells.”
“Recent studies indicated that combined treatment with vitamin C and MTX may inhibit MCF-7 and MDA-MB-231 breast cancer cell growth through G2/M elongation.”
“The aim of the present study was to determine whether combined treatment with low-dose vitamin C and MTX inhibits TNBC cell growth and to investigate the mechanisms of vitamin C/MTX-induced cytotoxicity.”
Combined treatment with vitamin C and methotrexate inhibits triple-negative breast cancer cell growth by increasing H2O2 accumulation and activating caspase-3 and p38 pathways.“Weak organic acids including salicylates, probenicid and vitamin C are known to compete with methotrexate for hydrogen-ion-dependent membrane transport, which may be inhibited by omeprazole.”
“From the results of this study, we were able to observe that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX.”
“ Vit C can ameliorate the toxic effect of MTX in liver and kidney tissues of rat.”
Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats.“Furthermore, MTX caused a significant decrease in the activities of hepatic enzymic antioxidants (superoxide dismutase, catalase, glutathione S-transferase) and nonenzymic antioxidants ( Vitamin C and glutathione), followed by a significant increase in hepatic malondialdehyde content.”
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