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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Vitamin C


Vitamin C

Research Papers that Mention the Interaction

However, combined low-dose vitamin C and MTX had synergistic anti-proliferative/cytotoxic effects on TNBC cells.
Recent studies indicated that combined treatment with vitamin C and MTX may inhibit MCF-7 and MDA-MB-231 breast cancer cell growth through G2/M elongation.
The aim of the present study was to determine whether combined treatment with low-dose vitamin C and MTX inhibits TNBC cell growth and to investigate the mechanisms of vitamin C/MTX-induced cytotoxicity.
Oncology reports  •  2017  |  View Paper
Weak organic acids including salicylates, probenicid and vitamin C are known to compete with methotrexate for hydrogen-ion-dependent membrane transport, which may be inhibited by omeprazole.
Cancer Chemotherapy and Pharmacology  •  1999  |  View Paper
From the results of this study, we were able to observe that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX.
Vit C can ameliorate the toxic effect of MTX in liver and kidney tissues of rat.
Physiology international  •  2017  |  View Paper
Furthermore, MTX caused a significant decrease in the activities of hepatic enzymic antioxidants (superoxide dismutase, catalase, glutathione S-transferase) and nonenzymic antioxidants ( Vitamin C and glutathione), followed by a significant increase in hepatic malondialdehyde content.
Journal of xenobiotics  •  2016  |  View Paper