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“Alteration of folate metabolism and/or vitamin B12 levels through intravenous or intrathecal administration of MTX might exist, although vitamin B12 and other essential nutrients were managed using intravenous hyperalimentation.”
Neuropathology : official journal of the Japanese Society of Neuropathology • 2014 | View Paper
“In addition, the new observation was made that patients under treatment with Mtx develop decreasing serum concentrations of B12 , possibly due to an impaired B12-absorption.”