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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“Alteration of folate metabolism and/or vitamin B12 levels through intravenous or intrathecal administration of MTX might exist, although vitamin B12 and other essential nutrients were managed using intravenous hyperalimentation.”
Myelopathy mimicking subacute combined degeneration in a Down syndrome patient with methotrexate treatment for B lymphoblastic leukemia: Report of an autopsy case“We suggest that Vit B12 can be used to reduce the toxic effects of MTX.”
Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity.“Consequently, Vit B12 potentially is a protective agent against damage caused by MTX.”
“We investigated Vit B12 as a possible protective agent against testicular damage caused by MTX treatment.”
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