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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Methotrexate
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“Alteration of folate metabolism and/or vitamin B12 levels through intravenous or intrathecal administration of MTX might exist, although vitamin B12 and other essential nutrients were managed using intravenous hyperalimentation.”
Myelopathy mimicking subacute combined degeneration in a Down syndrome patient with methotrexate treatment for B lymphoblastic leukemia: Report of an autopsy case“In addition, the new observation was made that patients under treatment with Mtx develop decreasing serum concentrations of B12 , possibly due to an impaired B12-absorption.”
“Results demonstrate that MTX can potentiate a choline-deficient fatty liver and block the lipotropic effect of vitamin B 12 .”
Interaction of methotrexate with lipotropic factors in rat liver.
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