supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago
drug:
Methotrexate
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“Alteration of folate metabolism and/or vitamin B12 levels through intravenous or intrathecal administration of MTX might exist, although vitamin B12 and other essential nutrients were managed using intravenous hyperalimentation.”
Myelopathy mimicking subacute combined degeneration in a Down syndrome patient with methotrexate treatment for B lymphoblastic leukemia: report of an autopsy case.“In addition, the new observation was made that patients under treatment with Mtx develop decreasing serum concentrations of B12 , possibly due to an impaired B12-absorption.”
“Results demonstrate that MTX can potentiate a choline-deficient fatty liver and block the lipotropic effect of vitamin B 12 .”
Interaction of methotrexate with lipotropic factors in rat liver.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback