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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Methotrexate and Vitamin B 12

supplement:

Vitamin B 12

Research Papers that Mention the Interaction

Alteration of folate metabolism and/or vitamin B12 levels through intravenous or intrathecal administration of MTX might exist, although vitamin B12 and other essential nutrients were managed using intravenous hyperalimentation.
Neuropathology : official journal of the Japanese Society of Neuropathology  •  2014  |  View Paper
In addition, the new observation was made that patients under treatment with Mtx develop decreasing serum concentrations of B12 , possibly due to an impaired B12-absorption.
The British journal of dermatology  •  1972  |  View Paper
Results demonstrate that MTX can potentiate a choline-deficient fatty liver and block the lipotropic effect of vitamin B 12 .
Biochemical pharmacology  •  1975  |  View Paper