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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Methotrexate and Vitamin A

supplement:

Vitamin A

Research Papers that Mention the Interaction

CONCLUSIONS Both vitamin A and leucovorin provided significant protection against genetic damage induced by methotrexate.
Clinics  •  2008  |  View Paper
The MTX treatment decreased retinol concentration in plasma of mice and the coadministration of DHA maintained its concentration to the level of control mice.
Life sciences  •  1998  |  View Paper
MTX treatment decreased permeability and VA coadministration prevented the decrease.
Cancer Chemotherapy and Pharmacology  •  1996  |  View Paper
Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage.
Pharmacology & toxicology  •  1993  |  View Paper
Thus, although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in crypt cells.
Pharmacology & toxicology  •  1991  |  View Paper
Oral administration of 6,000 IU vitamin A could help to reduce β-hCG levels in low-risk GTN patients who receive MTX chemotherapy..
Vitamin A also increases the effectiveness of MTX by inducing more malignant cell death than MTX alone.
Asian Pacific journal of cancer prevention : APJCP  •  2020  |  View Paper
Combination therapy of Methotrexate and Vitamin A in low risk GTN is associated with shorter duration of chemotherapy.
Iranian journal of pharmaceutical research : IJPR  •  2018  |  View Paper