Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Methotrexate and Vitamin A

supplement:

Vitamin A

Research Papers that Mention the Interaction

Combination therapy of Methotrexate and Vitamin A in low risk GTN is associated with shorter duration of chemotherapy.
Iranian journal of pharmaceutical research : IJPR  •  2018  |  View Paper
Vit E administration with MTX resulted in a significant increasing in the level of %ID/g.
Nuclear medicine review. Central & Eastern Europe  •  2018  |  View Paper
Vit E treatment significantly attenuated the severity of intestinal injury caused by MTX via inhibiting induced nitric oxide synthase levels and NF-κB p65 activation.
Analytical and quantitative cytopathology and histopathology  •  2016  |  View Paper
CONCLUSIONS Both vitamin A and leucovorin provided significant protection against genetic damage induced by methotrexate.
CONCLUSIONS Both vitamin A and leucovorin provided significant protection against genetic damage induced by methotrexate.
Clinics  •  2008  |  View Paper
The pre- and post-treatment administration of VA decreased the severity of jejunal damage caused by MTX treatment.
The pre- and post-treatment administration of VA decreased the severity of jejunal damage caused by MTX treatment.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre  •  2004  |  View Paper
The MTX treatment decreased retinol concentration in plasma of mice and the coadministration of DHA maintained its concentration to the level of control mice.
Life sciences  •  1998  |  View Paper
MTX treatment decreased permeability and VA coadministration prevented the decrease.
Cancer Chemotherapy and Pharmacology  •  1996  |  View Paper
Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage.
Pharmacology & toxicology  •  1993  |  View Paper
Thus, although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in crypt cells.
Pharmacology & toxicology  •  1991  |  View Paper