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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Vitamin A
Research Papers that Mention the Interaction
“Oral administration of 6,000 IU vitamin A could help to reduce β-hCG levels in low-risk GTN patients who receive MTX chemotherapy.”
“Oral administration of 6,000 IU vitamin A could help to reduce β-hCG levels in low-risk GTN patients who receive MTX chemotherapy..”
“ Vitamin A also increases the effectiveness of MTX by inducing more malignant cell death than MTX alone.”
Efficacy of Oral Vitamin A in Reducing β-hCG Levels in Low-Risk Gestational Trophoblastic Neoplasia Patients“CONCLUSIONS Both vitamin A and leucovorin provided significant protection against genetic damage induced by methotrexate.”
A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow“The MTX treatment decreased retinol concentration in plasma of mice and the coadministration of DHA maintained its concentration to the level of control mice.”
“ MTX treatment decreased permeability and VA coadministration prevented the decrease.”
“Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage.”
“Thus, although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in crypt cells.”
“Combination therapy of Methotrexate and Vitamin A in low risk GTN is associated with shorter duration of chemotherapy.”
Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia)
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