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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Methotrexate and Tyrosine



Research Papers that Mention the Interaction

Tyrosine 22 and arginine 22 relieve short contacts to methotrexate and NADPH by occupying low probability conformations, but this is unnecessary for phenylalanine 22 in the piritrexim complex.
The Journal of Biological Chemistry  •  1995  |  View Paper
At the biochemical level, … be disturbed by MTX : MTX may deplete the cell of the de novo synthesis of purine nucleotides and thymidylate through its action on dihydrofolate … of phenylalanine-hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin), and hence interfere with the supply of the neurotransmitters derived from tyrosine ….
Archives francaises de pediatrie  •  1991  |  View Paper
Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively.
Toxicology  •  1985  |  View Paper