Possible Interaction: Methotrexate and Tyrosine

“ Tyrosine 22 and arginine 22 relieve short contacts to methotrexate and NADPH by occupying low probability conformations, but this is unnecessary for phenylalanine 22 in the piritrexim complex.”

“At the biochemical level, … be disturbed by MTX : MTX may deplete the cell of the de novo synthesis of purine nucleotides and thymidylate through its action on dihydrofolate … of phenylalanine-hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin), and hence interfere with the supply of the neurotransmitters derived from tyrosine ….”

“1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.”