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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Tyrosine



Research Papers that Mention the Interaction

Tyrosine 22 and arginine 22 relieve short contacts to methotrexate and NADPH by occupying low probability conformations, but this is unnecessary for phenylalanine 22 in the piritrexim complex.
The Journal of Biological Chemistry  •  1995  |  View Paper
At the biochemical level, … be disturbed by MTX : MTX may deplete the cell of the de novo synthesis of purine nucleotides and thymidylate through its action on dihydrofolate … of phenylalanine-hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin), and hence interfere with the supply of the neurotransmitters derived from tyrosine ….
Archives francaises de pediatrie  •  1991  |  View Paper
1 hour prior to methotrexate prevented the inhibition of transmucosal transport of both glucose and tyrosine.
Drug-nutrient interactions  •  1987  |  View Paper