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Discover Supplement-Drug Interactions

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Possible Interaction: Methotrexate and Tyrosine

supplement:

Tyrosine

Research Papers that Mention the Interaction

At the biochemical level, … be disturbed by MTX : MTX may deplete the cell of the de novo synthesis of purine nucleotides and thymidylate through its action on dihydrofolate … of phenylalanine-hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin), and hence interfere with the supply of the neurotransmitters derived from tyrosine ….
Archives francaises de pediatrie  •  1991  |  View Paper
Tyrosine 22 and arginine 22 relieve short contacts to methotrexate and NADPH by occupying low probability conformations, but this is unnecessary for phenylalanine 22 in the piritrexim complex.
  •  1995  |  View Paper
Using the everted sac technique, the rates of D-glucose and L-tyrosine transport were decreased by MTX to 10.9 and 6.3 mumol/g/h from control values of 35.0 and 10.0 mumol/g/h, respectively.
Toxicology  •  1985  |  View Paper