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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Methotrexate and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

Retinoic acid amide exhibited a synergistic effect on antiproliferative effects of methotrexate in lung cancer cells.
Thus, retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate.
Tumor Biology  •  2015  |  View Paper
In terms of the effects of methotrexate or retinoid on the occurrence of cerebrovascular disease, a significant protection effect (HR = 0.50; 95% CI = 0.27-0.92; p = 0.0264) was found for patients with methotrexate prescription.
Acta dermato-venereologica  •  2012  |  View Paper
Because of the additive effect of undesirable side effects, the combination of retinoids and potentially hepatotoxic molecules especially methotrexate and of isotretinoin and potentially photosensitizing molecules should be avoided.
Annales de dermatologie et de venereologie  •  1991  |  View Paper
Upon treatment of methotrexate‐resistant (F9‐MTXr) cells with retinoic acid , loss of the amplified DNA in the absence of selection was significantly retarded.
International journal of cancer  •  1991  |  View Paper
L’acitrétine et le méthotrexate sont formellement contre-indiqués.
European Journal of Dermatology  •  2020  |  View Paper
When the retinoid is combined with methotrexate or PUVA, it strengthens the effectiveness of treatment by exhibiting combined actions of each agent and decreasing the side effects by lowering the doses of total UVA irradiation4.
Annals of dermatology  •  2013  |  View Paper