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Discover Supplement-Drug Interactions

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Possible Interaction: Methotrexate and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

Because of the additive effect of undesirable side effects, the combination of retinoids and potentially hepatotoxic molecules especially methotrexate and of isotretinoin and potentially photosensitizing molecules should be avoided.
Because of the additive effect of undesirable side effects, the combination of retinoids and potentially hepatotoxic molecules especially methotrexate and of isotretinoin and potentially photosensitizing molecules should be avoided.
Annales de dermatologie et de venereologie  •  1991  |  View Paper
When the retinoid is combined with methotrexate or PUVA, it strengthens the effectiveness of treatment by exhibiting combined actions of each agent and decreasing the side effects by lowering the doses of total UVA irradiation4.
Annals of dermatology  •  2013  |  View Paper
An enhanced effect was observed in the combined administration of all-trans RA and methotrexate or actinomycin-D. The secretion of hCG increased 4-fold to 9-fold by the addition of 1 microM all-trans RA.
The journal of obstetrics and gynaecology research  •  1997  |  View Paper
Retinoic acid amide exhibited a synergistic effect on antiproliferative effects of methotrexate in lung cancer cells.
Thus, retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate.
Tumor Biology  •  2015  |  View Paper