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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Tretinoin
Research Papers that Mention the Interaction
“ Retinoic acid amide exhibited a synergistic effect on antiproliferative effects of methotrexate in lung cancer cells.”
“Thus, retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate.”
Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis“ L’acitrétine et le méthotrexate sont formellement contre-indiqués.”
“In terms of the effects of methotrexate or retinoid on the occurrence of cerebrovascular disease, a significant protection effect (HR = 0.50; 95% CI = 0.27-0.92; p = 0.0264) was found for patients with methotrexate prescription.”
“Because of the additive effect of undesirable side effects, the combination of retinoids and potentially hepatotoxic molecules especially methotrexate and of isotretinoin and potentially photosensitizing molecules should be avoided.”
“Upon treatment of methotrexate‐resistant (F9‐MTXr) cells with retinoic acid , loss of the amplified DNA in the absence of selection was significantly retarded.”
Retinoic‐acid‐induced differentiation prevents gene amplification in teratocarcinoma stem cells“When the retinoid is combined with methotrexate or PUVA, it strengthens the effectiveness of treatment by exhibiting combined actions of each agent and decreasing the side effects by lowering the doses of total UVA irradiation4.”
Long-Term Follow-Up of Refractory Mycosis Fungoides Which Achieved Remission with the Addision of Isotretinoin to Methotrexate and Psoralen Plus Ultraviolat A Therapy
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