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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Methotrexate and Thiamine

supplement:

Thiamine

Research Papers that Mention the Interaction

Conclusion: The mechanism of action of MTX and thiamin is antiparallel to each other and hence their concomitant administration may lead to inefficient anticancer activity of MTX.
Nutrition and cancer  •  2019  |  View Paper
1) The inhibition of growth produced by amethopterin can be prevented by thiamin or by thiamin plus pyridoxal, but not by comparable concentrations of folic or folinic acids.
3) In washed-cell suspensions thiamin interferes with the inhibitory action of amethopterin on the synthesis of folinic acid.
Biochemical pharmacology  •  1961  |  View Paper
Guthrie et al. (1956) have shown that another group of compounds, cocarboxylase, thiamine , and thiamine pyrimidine, will, however, prevent the inhibitory effect of amethopterin on B. subtilis.
Journal of bacteriology  •  1960  |  View Paper
An inferred inhibition of thiamine synthesis by amethopterin was substantiated by Pine and Guthrie (1959) but it did not appear to be critical in impeding growth.
Journal of bacteriology  •  1960  |  View Paper
They suggested that inhibition of the synthesis of thiamine was the primary effect of amethopterin in this organism.
Journal of bacteriology  •  1959  |  View Paper