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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Thiamine
Research Papers that Mention the Interaction
“Conclusion: The mechanism of action of MTX and thiamin is antiparallel to each other and hence their concomitant administration may lead to inefficient anticancer activity of MTX.”
Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats“1) The inhibition of growth produced by amethopterin can be prevented by thiamin or by thiamin plus pyridoxal, but not by comparable concentrations of folic or folinic acids.”
“3) In washed-cell suspensions thiamin interferes with the inhibitory action of amethopterin on the synthesis of folinic acid.”
The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria.“Guthrie et al. (1956) have shown that another group of compounds, cocarboxylase, thiamine , and thiamine pyrimidine, will, however, prevent the inhibitory effect of amethopterin on B. subtilis.”
“An inferred inhibition of thiamine synthesis by amethopterin was substantiated by Pine and Guthrie (1959) but it did not appear to be critical in impeding growth.”
“They suggested that inhibition of the synthesis of thiamine was the primary effect of amethopterin in this organism.”
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