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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Methotrexate and Serum Albumin, Human

Research Papers that Mention the Interaction

The biological activity of DCM, which was slightly higher on an equimolar basis than that of MTX in HA-free culture medium, was reduced to a much lower level than that of MTX in the presence of HA (2.5 g/dl) in the culture medium.
Thus, on a basis of the dose causing 90% inhibition, the equitoxic concentration of MTX increased only about 2-fold in the presence of HA , while that of DCM increased about 5-fold.
Cancer research  •  1979  |  View Paper
Furthermore, we discuss some factors that influence methotrexate binding to HSA.
Site marker competitive displacement experiments and a molecular modeling approach demonstrated that methotrexate binds with appropriate affinity to site I (subdomain IIA) of HSA.
Luminescence : the journal of biological and chemical luminescence  •  2017  |  View Paper
MTX and CF, which are used together in high dose therapy, compete for HSA binding.
European Journal of Clinical Pharmacology  •  2004  |  View Paper