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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Methotrexate
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“The biological activity of DCM, which was slightly higher on an equimolar basis than that of MTX in HA-free culture medium, was reduced to a much lower level than that of MTX in the presence of HA (2.5 g/dl) in the culture medium.”
“Thus, on a basis of the dose causing 90% inhibition, the equitoxic concentration of MTX increased only about 2-fold in the presence of HA , while that of DCM increased about 5-fold.”
A comparison of the biological effects of dichloromethotrexate and methotrexate on human leukemic cells in culture.“Furthermore, we discuss some factors that influence methotrexate binding to HSA.”
“Site marker competitive displacement experiments and a molecular modeling approach demonstrated that methotrexate binds with appropriate affinity to site I (subdomain IIA) of HSA.”
“ MTX and CF, which are used together in high dose therapy, compete for HSA binding.”
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