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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Serine
Research Papers that Mention the Interaction
“The only exception was substitution of Arg375 with serine , which had no effect on cGMP transport but significantly decreased the affinity of MTX.”
Functional Role of Arginine 375 in Transmembrane Helix 6 of Multidrug Resistance Protein 4 (MRP4/ABCC4)“The serine 31 mutation had little effect on the steady-state kinetic properties of the enzyme but produced a 100-fold increase in the dissociation constant (Kd) for the inhibitor methotrexate.”
“Furthermore, 10 nM MTX removed the block of the G1-S transition operated by antimycin A or pyruvate, an effect which was enhanced in the presence of F. Finally, the stimulatory effect of 10 nM MTX was inhibited in the presence of serine.”
Low-dose methotrexate enhances cycling of highly anaplastic cancer cells“ MTX also blocked the transfer of the beta carbon from serine into methionine.”
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