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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Serine



Research Papers that Mention the Interaction

The only exception was substitution of Arg375 with serine , which had no effect on cGMP transport but significantly decreased the affinity of MTX.
Molecular Pharmacology  •  2008  |  View Paper
The serine 31 mutation had little effect on the steady-state kinetic properties of the enzyme but produced a 100-fold increase in the dissociation constant (Kd) for the inhibitor methotrexate.
The Journal of biological chemistry  •  1989  |  View Paper
Furthermore, 10 nM MTX removed the block of the G1-S transition operated by antimycin A or pyruvate, an effect which was enhanced in the presence of F. Finally, the stimulatory effect of 10 nM MTX was inhibited in the presence of serine.
Cell cycle  •  2017  |  View Paper
MTX also blocked the transfer of the beta carbon from serine into methionine.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper