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“In suspension cells but not in adherent cells there was a decrease in the levels of S-adenosylmethionine and polyamines after methotrexate treatment.”
Proceedings of the National Academy of Sciences • 2019 | View Paper
“Results SAM levels decreased significantly during methotrexate therapy (-16.1 nmol/L (-144.0 –+46.0), p<0.001), while SAH levels and the SAM:SAH ratio did not change significantly.”
“Orally administered SAM has been shown to increase CSF levels and substitution of SAM to patients treated with high-dose and intrathecal MTX deserves further investigation.”
Journal of Biological Chemistry • 2004 | View Paper
“Accordingly, both choline deficiency and MTX treatment reduced the AdoMet to AdoHcy ratio.”
“ MTX increased the amount of Hcy about 2-fold in serum, liver and kidney, and decreased the amount of AdoMet in liver and kidney, whereas the AdoHcy content in these tissues was essentially unaffected.”
Cancer Chemotherapy and Pharmacology • 2004 | View Paper
“Depletion of the hepatic SAM pool has likewise been shown to mediate, at least in part, the hepatotoxic effects of ethanol, methotrexate , and niacinamide.”