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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Methotrexate
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“In suspension cells but not in adherent cells there was a decrease in the levels of S-adenosylmethionine and polyamines after methotrexate treatment.”
Methotrexate differentially affects growth of suspension and adherent cells.“ Methotrexate , a pillar in the treatment of cancer since 1948, decreases SAM levels.”
“Results SAM levels decreased significantly during methotrexate therapy (-16.1 nmol/L (-144.0 –+46.0), p<0.001), while SAH levels and the SAM:SAH ratio did not change significantly.”
“Orally administered SAM has been shown to increase CSF levels and substitution of SAM to patients treated with high-dose and intrathecal MTX deserves further investigation.”
“ Methotrexate resistance was also correlated to increased cellular S-adenosylmethionine levels.”
Differential Protein Expression Analysis of Leishmania major Reveals Novel Roles for Methionine Adenosyltransferase and S-Adenosylmethionine in Methotrexate Resistance*“Accordingly, both choline deficiency and MTX treatment reduced the AdoMet to AdoHcy ratio.”
“ MTX increased the amount of Hcy about 2-fold in serum, liver and kidney, and decreased the amount of AdoMet in liver and kidney, whereas the AdoHcy content in these tissues was essentially unaffected.”
“Depletion of the hepatic SAM pool has likewise been shown to mediate, at least in part, the hepatotoxic effects of ethanol, methotrexate , and niacinamide.”
“ MTX treatment alone lowered hepatic concentrations of PCho (to 48% control), GroPCho (to 69% control), betaine (to 55% control), and AdoMet (to 75% control).”
Effects of choline deficiency and methotrexate treatment upon rat liver.
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