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Last Updated: 7 months ago

Possible Interaction: Methotrexate and S-Adenosylmethionine

Research Papers that Mention the Interaction

In suspension cells but not in adherent cells there was a decrease in the levels of S-adenosylmethionine and polyamines after methotrexate treatment.
The international journal of biochemistry & cell biology  •  2004  |  View Paper
Methotrexate , a pillar in the treatment of cancer since 1948, decreases SAM levels.
Proceedings of the National Academy of Sciences  •  2019  |  View Paper
Results SAM levels decreased significantly during methotrexate therapy (-16.1 nmol/L (-144.0 –+46.0), p<0.001), while SAH levels and the SAM:SAH ratio did not change significantly.
PloS one  •  2018  |  View Paper
Orally administered SAM has been shown to increase CSF levels and substitution of SAM to patients treated with high-dose and intrathecal MTX deserves further investigation.
Pediatric blood & cancer  •  2009  |  View Paper
Methotrexate resistance was also correlated to increased cellular S-adenosylmethionine levels.
Journal of Biological Chemistry  •  2004  |  View Paper
Accordingly, both choline deficiency and MTX treatment reduced the AdoMet to AdoHcy ratio.
MTX increased the amount of Hcy about 2-fold in serum, liver and kidney, and decreased the amount of AdoMet in liver and kidney, whereas the AdoHcy content in these tissues was essentially unaffected.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
Depletion of the hepatic SAM pool has likewise been shown to mediate, at least in part, the hepatotoxic effects of ethanol, methotrexate , and niacinamide.
Medical hypotheses  •  2000  |  View Paper
MTX treatment alone lowered hepatic concentrations of PCho (to 48% control), GroPCho (to 69% control), betaine (to 55% control), and AdoMet (to 75% control).
The Journal of nutritional biochemistry  •  1990  |  View Paper