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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Rutin



Research Papers that Mention the Interaction

In MDA‐MB‐231 cells, 20 μM rutin enhanced cytotoxicity related to cyclophosphamide and methotrexate.
Phytotherapy research : PTR  •  2017  |  View Paper
Extracts of soybean, Gymnema sylvestre, black cohosh and passion flower and rutin strongly inhibited BCRP-mediated transport of MTX at 1 mg/ml, while inhibition by chlorella, milk thistle and Siberian ginseng extracts was weak.
Drug metabolism and pharmacokinetics  •  2010  |  View Paper
ConclusionThe positive modulation of MTX toxicity could be attributed to the free radical scavenging and anti-inflammatory (dual inhibition of arachidonic acid pathways) potential of rutin.
The intestinal contents were scrutinized physiologically (pH, total acidity, free acidity, CMDI), biochemically (TBARS, protein carbonyl, SOD, catalase and GSH) and for immunoregulatory cytokines (IL-2, IL-4 and IL-10).Results and DiscussionThe administration of rutin demonstrated significant protection against intestinal lesions damaged by MTX.
BMC Complementary and Alternative Medicine  •  2016  |  View Paper