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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Methotrexate and Retinaldehyde

Research Papers that Mention the Interaction

Methotrexate also enhanced all-trans retinoic acid-induced cell differentiation in three patient-derived osteosarcoma cell lines, and the modulation of expression of the differentiation-related genes was also shown.
Cancer Cell International  •  2016  |  View Paper
An enhanced effect was observed in the combined administration of all-trans RA and methotrexate or actinomycin-D. The secretion of hCG increased 4-fold to 9-fold by the addition of 1 microM all-trans RA.
The journal of obstetrics and gynaecology research  •  1997  |  View Paper
CONCLUSIONS High dose intravitreal methotrexate injection may cause significant ultrastructural changes in the rabbit retina in varying severity.
This finding may highlight the potential side effects of methotrexate on human retina in higher doses.
Indian journal of ophthalmology  •  2013  |  View Paper