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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Quercetin
Research Papers that Mention the Interaction
“A significant reduction in the levels of knee-joint inflammatory mediators were observed with combined quercetin and methotrexate treatment.”
Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis“The results also showed that the concurrent administration of quercetin and methotrexate did not offer greater protection than the administration of a single agent.”
“Conclusions: In conclusion, renal toxic effects of MTX may be alleviated by QE.”
“However, QE significantly suppressed MDA level, compensated deficits in the anti-oxidant defenses [reduced SOD, GSH-Px, and CAT levels] in kidney tissue resulted from MTX administration.”
“Because increased GGH expressions were repeatedly associated with resistance to methotrexate , concomitant intake with quercetin should be monitored carefully.”
“Pre-treatment of mice by gavage …/day for 10 days) and QE (50mg/kgbw/day for 10 days) caused a significant decrease in CAs and … aberrant cells with CAs induced by intramuscular treatment of the mice with MTX (10mg/kgbw/day for 3 days), … group treated with MTX alone.”
“ QT co-administered with MX reversed this hepatotoxicity (p<0.05).”
Anti-inflammatory and Hepatoprotective Effects of Quercetin in an Experimental Model of Rheumatoid Arthritis.
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