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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“In addition, corticosteroid and methotrexate therapy for JIA may increase blood Phe concentration.”
Phenylketonuria and juvenile idiopathic arthritis: a case report“A post-infusion increase in PHE/TYR of 571% after 22 hours in one patient and of 410% after 30 hours in another were associated with marked MTX toxicity.”
“Molecular modeling of Leu22----Phe supports the concept of the importance of Leu22 in the active site of the enzyme and indicates that replacement with phenylalanine will decrease the binding of methotrexate.”
Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII.“Treatment with loading doses of phenylalanine along with methotrexate reduced the level of tetrahydrobiopterin in liver.”
“ Methotrexate , which inhibits the phenylalanine hydroxylase system by preventing regeneration of the tetrahydropteridine cofactor, caused parallel inhibition of the in vivo assay as well as when the conversion of phenylalanine to tyrosine was measured in liver slices.”
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