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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Phenylalanine

Research Papers that Mention the Interaction

In addition, corticosteroid and methotrexate therapy for JIA may increase blood Phe concentration.
BMC Pediatrics  •  2021  |  View Paper
A post-infusion increase in PHE/TYR of 571% after 22 hours in one patient and of 410% after 30 hours in another were associated with marked MTX toxicity.
Medical and pediatric oncology  •  1982  |  View Paper
Molecular modeling of Leu22----Phe supports the concept of the importance of Leu22 in the active site of the enzyme and indicates that replacement with phenylalanine will decrease the binding of methotrexate.
The Journal of biological chemistry  •  1990  |  View Paper
Treatment with loading doses of phenylalanine along with methotrexate reduced the level of tetrahydrobiopterin in liver.
Molecular pharmacology  •  1983  |  View Paper
Methotrexate , which inhibits the phenylalanine hydroxylase system by preventing regeneration of the tetrahydropteridine cofactor, caused parallel inhibition of the in vivo assay as well as when the conversion of phenylalanine to tyrosine was measured in liver slices.
The Journal of biological chemistry  •  1975  |  View Paper