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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Methotrexate and Niacin

supplement:

Niacin

Research Papers that Mention the Interaction

NIC significantly solublized MTX by forming hydrogen bonds with MTX.
International journal of pharmaceutics  •  2021  |  View Paper
Nicotinamide decreased the methotrexate‐induced hepatotoxicity.
The combination of nicotinamide and thalidomide or methotrexate provided a powerful synergistic inhibition of murine collagen‐induced arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  2003  |  View Paper
If methotrexate is administered in conjunction with either nicotinamide or methionine, the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.
General pharmacology  •  1999  |  View Paper