supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Licorice
Research Papers that Mention the Interaction
“In conclusion, the concurrent use of GZ or licorice with MTX should be with caution.”
Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats.“ Licorice extract averted the decrease in serum testosterone and the increase in IL-1β and IL-6 levels induced by MTX.”
“ Licorice extracts positively regulated the expression of steroidogenesis genes suppressed by MTX , increased antioxidant enzymes (glutathione peroxidase, reduced glutathione, and catalase) and reduced biomarker of oxidative stress (testicular malondialdehyde) and inflammatory cytokines (IL-1 and -6).”
“Pretreatment with licorice extract ameliorated the toxic effects of MTX on total proteins, albumin, and globulins and oxidative stress biomarkers and reversed the effect of MTX on examined serum and tissue antioxidants.”
The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback