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Possible Interaction: Methotrexate and Levomefolate

supplement:

Levomefolate

Research Papers that Mention the Interaction

In contrast, when these patients received intrathecal MTX without rescue, 5-methyltetrahydrofolate concentrations were significantly decreased 12 days after the first MTX administration.
Pediatric blood & cancer  •  2009  |  View Paper
MTX (0-1 microM) was associated with a dose- and time-dependent reduction in 5-methyltetrahydrofolate (5-methyl-THF) in both cell lines.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
MTX , following by mTHF after a delay of 8-24 h, caused a substantial killing of lymphoid leukemia cells, greater than the effect of either drug alone.
Leukemia  •  1992  |  View Paper
Methotrexate reduces intracellular pools of 5-methyltetrahydrofolate and could result in reduced conversion of homocysteine to methionine by methionine synthetase.
Cancer research  •  1989  |  View Paper
Moreover, methotrexate influx was inhibited by 5-methyltetrahydrofolate and folate, and the inhibition constants (Ki) of the latter compounds were equivalent to their Kt values for half-maximal influx.
Biochemical pharmacology  •  1987  |  View Paper
Folate and methyltetrahydrofolate competitivity inhibited amethopterin uptake with apparent Ki values of 8 and 0.7 muM, respectively.
The Ki for amethopterin when added to increasing concentrations of methyltetrahydrofolate was 5.2 muM, a value about the same as that of the Km.
Biochimica et biophysica acta  •  1976  |  View Paper
The selective toxicity of antifolates for a variety of cancers can be improved, as illustrated by the combined administration of N5-methyltetrahydrofolate and methotrexate in tissue culture.
Proceedings of the National Academy of Sciences of the United States of America  •  1975  |  View Paper
Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate , substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect.
The Journal of pharmacy and pharmacology  •  2009  |  View Paper
In contrast, the uptake of 5-methyltetrahydrofolate by the kidney slices was inhibited by MTX , folate, and dibromosulfophthalein, but not by PAH and PCG.
The Journal of pharmacology and experimental therapeutics  •  2004  |  View Paper
MTX administration produced decreased plasma 5-MF levels.
We conclude that the inhibition of reabsorption of 5-MF in the renal tube by concurrent administration of MTX and FA must be one of the causal factors for the demonstrated decrease in the plasma 5-MF levels in rats.
The Journal of veterinary medical science  •  1998  |  View Paper
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