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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Methotrexate and Glutamic Acid

Research Papers that Mention the Interaction

The most striking effects were seen with sheep liver DHFR, where polyglutamylation of MTX causes stepwise decreases in the concentration required for 50% inhibition (IC50) with each additional Glu residue until MTX with a total of six Glu residues has an IC50 value 1/3 that of MTX.
Cancer research  •  1986  |  View Paper
In addition, MTX plus 20 mM glutamic acid was able to improve the synthesis of MTX-PG5.
Materials and Methods: In this work, we demonstrated that the combination treatment of methotrexate and 5 and 10 mM glutamic acid could enhance methotrexate cytotoxicity in CCRF-SB (B-ALL) cells.
Medicina  •  2019  |  View Paper
Enzymic cleavage of 4-amino-N10-methylpteroylglutamic acid (methotrexate) was strongly inhibited by the product l-glutamic acid , and to a lesser extent by l-aspartic acid, while d-glutamic acid was ineffective.
The Journal of biological chemistry  •  1971  |  View Paper