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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Methotrexate and Glutamic Acid

Research Papers that Mention the Interaction

In addition, MTX plus 20 mM glutamic acid was able to improve the synthesis of MTX-PG5.
Materials and Methods: In this work, we demonstrated that the combination treatment of methotrexate and 5 and 10 mM glutamic acid could enhance methotrexate cytotoxicity in CCRF-SB (B-ALL) cells.
Medicina  •  2019  |  View Paper
The most striking effects were seen with sheep liver DHFR, where polyglutamylation of MTX causes stepwise decreases in the concentration required for 50% inhibition (IC50) with each additional Glu residue until MTX with a total of six Glu residues has an IC50 value 1/3 that of MTX.
Cancer research  •  1986  |  View Paper
Enzymic cleavage of 4-amino-N10-methylpteroylglutamic acid (methotrexate) was strongly inhibited by the product l-glutamic acid , and to a lesser extent by l-aspartic acid, while d-glutamic acid was ineffective.
The Journal of biological chemistry  •  1971  |  View Paper