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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“In addition, MTX plus 20 mM glutamic acid was able to improve the synthesis of MTX-PG5.”
“Materials and Methods: In this work, we demonstrated that the combination treatment of methotrexate and 5 and 10 mM glutamic acid could enhance methotrexate cytotoxicity in CCRF-SB (B-ALL) cells.”
Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line“The most striking effects were seen with sheep liver DHFR, where polyglutamylation of MTX causes stepwise decreases in the concentration required for 50% inhibition (IC50) with each additional Glu residue until MTX with a total of six Glu residues has an IC50 value 1/3 that of MTX.”
Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.“Enzymic cleavage of 4-amino-N10-methylpteroylglutamic acid (methotrexate) was strongly inhibited by the product l-glutamic acid , and to a lesser extent by l-aspartic acid, while d-glutamic acid was ineffective.”
Purification and properties of carboxypeptidase G 1 .
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