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Discover Supplement-Drug Interactions

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Possible Interaction: Methotrexate and Ginseng

supplement:

Ginseng

Research Papers that Mention the Interaction

Biliary excretion, but not urinary excretion, of methotrexate decreased in the RGE repeated administration group, compared to that in the control group.
Consequently, the plasma concentrations of methotrexate slightly increased in the RGE repeated administration group.
Pharmacokinetic herb–drug interaction between RGE and methotrexate might occur owing to the decrease in the mRNA and protein levels of Mrp2.
Molecules  •  2018  |  View Paper
In the cell proliferation assay, WPG significantly enhanced the proliferation of RAW 264.7 macrophages and protected against cell regression in macrophages treated with methotrexate (MTX).
Taken together, these results provide the first evidence that WPG triggers immune responses through the prevention of macrophage cell regression caused by MTX and functional activation of macrophages.
The American journal of Chinese medicine  •  2010  |  View Paper