“Biliary excretion, but not urinary excretion, of methotrexate decreased in the RGE repeated administration group, compared to that in the control group.”
“Consequently, the plasma concentrations of methotrexate slightly increased in the RGE repeated administration group.”
“Pharmacokinetic herb–drug interaction between RGE and methotrexate might occur owing to the decrease in the mRNA and protein levels of Mrp2.”