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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Genistein



Research Papers that Mention the Interaction

Our in vitro studies showed that genistein in certain concentrations protected cultured SECs from MTX cytotoxic effects.
Journal of cellular physiology  •  2019  |  View Paper
In addition, genistein (a tyrosine phosphorylation inhibitor) significantly enhanced the resistance of L1210/0 cells to MTX.
Cancer letters  •  2015  |  View Paper
After 5 h of treatment with 50 microM genistein, methotrexate uptake was decreased by nearly 50% and the cells were protected from methotrexate cytotoxicity.
Oncology reports  •  1998  |  View Paper