Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Methotrexate and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Our in vitro studies showed that genistein in certain concentrations protected cultured SECs from MTX cytotoxic effects.
Journal of cellular physiology  •  2019  |  View Paper
In addition, genistein (a tyrosine phosphorylation inhibitor) significantly enhanced the resistance of L1210/0 cells to MTX.
Cancer letters  •  2015  |  View Paper
After 5 h of treatment with 50 microM genistein, methotrexate uptake was decreased by nearly 50% and the cells were protected from methotrexate cytotoxicity.
Oncology reports  •  1998  |  View Paper