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Possible Interaction: Methotrexate and Folate

supplement:

Folate

Research Papers that Mention the Interaction

CONCLUSIONS MTX toxicity, final dose, and efficacy are influenced by folate supplementation.
CONCLUSIONS MTX toxicity, final dose, and efficacy are influenced by folate supplementation.
Annals of the rheumatic diseases  •  2003  |  View Paper
OBJECTIVE To study (i) the influence of methotrexate (MTX) therapy on homocysteine and folate metabolism in patients with rheumatoid arthritis (RA), (… in the methylenetetrahydrofolate reductase gene (MTHFR) on the change in plasma homocysteine levels during MTX treatment, and (iii) the interference of folate and homocysteine metabolism … treatment with MTX.
OBJECTIVE To study (i) the influence of methotrexate (MTX) therapy on homocysteine and folate metabolism in patients with rheumatoid arthritis (RA), (… in the methylenetetrahydrofolate reductase gene (MTHFR) on the change in plasma homocysteine levels during MTX treatment, and (iii) the interference of folate and homocysteine metabolism … treatment with MTX.
Rheumatology  •  2002  |  View Paper
Folate deficiency occurs frequently in patients with rheumatoid arthritis; further, folate stores are decreased in patients with rheumatoid arthritis who take methotrexate , suggesting that impaired folate status is related to toxicity [24-26].
Annals of internal medicine  •  1994  |  View Paper
There is little agreement about the proper dosing or frequency of folate supplementation as many believe that daily folate supplementation can reduce methotrexate efficacy.
Dermatology online journal  •  2017  |  View Paper
These findings suggest that methotrexate neurotoxicity may be mediated by folate antagonism.
American journal of hematology  •  2017  |  View Paper
MTX inhibits several enzymes of the folate and nucleotide pathways.
Clinical Rheumatology  •  2017  |  View Paper
The toxicity of MTX also was found to be associated with the TT genotype in patients taking folate (OR = 1.893, 95 % CI = 1.283–2.793, p = 0.001).
Clinical Rheumatology  •  2014  |  View Paper
MTX exposure and folate deprivation in erythroblastoid cells resulted in a depletion of bioactive folate species that was associated with a shift to higher Gluavg values for several species, most notably tetrahydrofolate (THF) and 5,10-methylene-tetrahydrofolate (CH2 THF).
RESULTS Circulating folate levels were lower in JIA patients receiving MTX , with reduced levels of blood, plasma, and RBC 5-methyl-tetrahydrofolate (5mTHF) (P < 0.0001).
RESULTS Circulating folate levels were lower in JIA patients receiving MTX , with reduced levels of blood, plasma, and RBC 5-methyl-tetrahydrofolate (5mTHF) (P < 0.0001).
Arthritis & rheumatology  •  2014  |  View Paper
Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression.
Cancer Chemotherapy and Pharmacology  •  2014  |  View Paper
Particularly in cancer patients, MTX is given because of its ability to inhibit the folate pathway enzymes, including the enzymes DHFR and MTHFR.
Pharmacogenomics  •  2014  |  View Paper
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