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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Methotrexate and Folate



Research Papers that Mention the Interaction

Conclusions: MTX toxicity, final dose, and efficacy are influenced by folate supplementation.
Annals of the rheumatic diseases  •  2003  |  View Paper
OBJECTIVE To study (i) the influence of methotrexate (MTX) therapy on homocysteine and folate metabolism in patients with rheumatoid arthritis (RA), (… in the methylenetetrahydrofolate reductase gene (MTHFR) on the change in plasma homocysteine levels during MTX treatment, and (iii) the interference of folate and homocysteine metabolism … treatment with MTX.
Rheumatology  •  2002  |  View Paper
Folate deficiency occurs frequently in patients with rheumatoid arthritis; further, folate stores are decreased in patients with rheumatoid arthritis who take methotrexate , suggesting that impaired folate status is related to toxicity [24-26].
Annals of Internal Medicine  •  1994  |  View Paper
Inhibition of pathways of folate metabolism involving purine metabolism by MTX , have been traditionally emphasized as important in MTX efficacy.
Medical hypotheses  •  2019  |  View Paper
Indeed, the very first cancer chemotherapy, methotrexate , functions by blocking folate metabolism and therefore the synthesis of DNA and RNA and has more recently been successfully applied to other proliferative diseases, namely rheumatoid arthritis.
Biochemistry  •  2018  |  View Paper
Pharmacological inhibition of folate action by methotrexate during neurulation induces NTDs by inhibiting folate interaction with its uptake systems.
Development  •  2017  |  View Paper
In vivo inhibition of the folate pathway via methotrexate administration strongly impaired metastasis without altering growth of the subcutaneous tumor.
Pigment cell & melanoma research  •  2016  |  View Paper
Import was not affected by high concentrations of the antifolate drugs pyrimethamine and sulfadoxine, but was inhibited by the close folate analogue methotrexate.
Molecular and biochemical parasitology  •  2007  |  View Paper
MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the genes controlling their activity or the levels of folate cofactors can modulate drug efficacy and, thus, the sensitivity of a patient to MTX.
Pharmacogenomics  •  2004  |  View Paper
MTX deprives rapidly dividing cells of reduced folates that are necessary for thymidylate synthesis and de novo purine nucleotide synthesis.
Biochemical pharmacology  •  2000  |  View Paper
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