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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Methotrexate and Epigallocatechin Gallate

Research Papers that Mention the Interaction

The uptake of the PCFT substrate methotrexate MTX ) was competitively inhibited by EGCG as well (K(i) ≒ 15 µM).
Drug metabolism and pharmacokinetics  •  2014  |  View Paper
Combination therapy of MTX and EGCG significantly inhibited the development phase of arthritis, which is supported by histopathological, radiographical, and attenuation of overexpression of cartilage cytokines.
EGCG act as potent antioxidant and immunomodulator, suggesting that combined administration of MTX along with EGCG suppressed the development phase of arthritic progression in rats.
MTX and EGCG combination potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect (SOD, GSH, and catalase) as well as suppression of lipid peroxidation.
Inflammation  •  2012  |  View Paper