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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Methotrexate
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“The uptake of the PCFT substrate methotrexate MTX ) was competitively inhibited by EGCG as well (K(i) ≒ 15 µM).”
Effect of epigallocatechin gallate on drug transport mediated by the proton-coupled folate transporter.“Combination therapy of MTX and EGCG significantly inhibited the development phase of arthritis, which is supported by histopathological, radiographical, and attenuation of overexpression of cartilage cytokines.”
“EGCG act as potent antioxidant and immunomodulator, suggesting that combined administration of MTX along with EGCG suppressed the development phase of arthritic progression in rats.”
“ MTX and EGCG combination potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect (SOD, GSH, and catalase) as well as suppression of lipid peroxidation.”
A Novel Combination of Methotrexate and Epigallocatechin Attenuates the Overexpression of Pro-inflammatory Cartilage Cytokines and Modulates Antioxidant Status in Adjuvant Arthritic Rats
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