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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Methotrexate
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ MTX inhibited keratinocyte growth, which was enhanced synergistically by calcium.”
Can pretreatment serum calcium level predict the efficacy of methotrexate in the treatment of severe plaque psoriasis?“ MTX … calcium ionophore-driven LTB4 generation from the neutrophils of asthmatics (358.9 +/- 39.5 pg/10(6) cells vs 240.1 +/- 29.1 pg/10(…, p < 0.05) and attenuated PHA-induced mononuclear DNA synthesis as shown by a reduction in 3H-thymidine uptake and propidium iodide staining.”
“Leucovorin calcium is given to cancer patients receiving high-dose methotrexate to retard the onset of serious side effects.”
“We found that RANKL-dependent calcium Ca ) influx into osteoclast progenitors was significantly inhibited by MTX.”
Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors
“The MTX (1 ng/ml)-induced increase in [Ca2+]i was partially inhibited by the omission of extracellular Ca2+ (Ca2+e) or the addition of verapamil, but not by adding nifedipine, omega-agatoxin IVA, omega-conotoxin GVIA and omega-conotoxin MVIIC.”
“… methotrexate caused more frequent (from the second week on) the appearance of more intense degenerative changes, and from … of cardiomyocytes, local increase of acid phosphatase activity from the second week on, falling activity of calcium and magnesium dependent ATPases from the fifth … in the sixth week of the experiment.”
“Binding measurements with [3H]Methotrexate provide KD values of ca.”
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