Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Methotrexate and Calcium Supplement

Research Papers that Mention the Interaction

CaLa in combination with MTX induced reduced Met synthesis when CRC cell viability was reduced.
CaLa raised the antitumor effect of MTX via secondary role in the inhibition of the de novo nucleotide synthesis.
Combination therapy of MTX and CaLa could maximize the effectiveness of CRC treatment.
Nutrition and cancer  •  2017  |  View Paper
MTX … calcium ionophore-driven LTB4 generation from the neutrophils of asthmatics (358.9 +/- 39.5 pg/10(6) cells vs 240.1 +/- 29.1 pg/10(…, p < 0.05) and attenuated PHA-induced mononuclear DNA synthesis as shown by a reduction in 3H-thymidine uptake and propidium iodide staining.
Asian Pacific journal of allergy and immunology  •  1994  |  View Paper
After preincubation, the basophil leukocytes were challenged with anti-IgE, allergens or the calcium ionophore A23187 in the presence of 25 ng/ml TPA (12-o-tetradecanoyl-phorbol-13-acetate).A 9-hr preincubation with MTX produced significant inhibition of histamine release (>20%) at 500–50 μg/ml.
Agents and Actions  •  1988  |  View Paper
MTX inhibited keratinocyte growth, which was enhanced synergistically by calcium.
Journal of the American Academy of Dermatology  •  2015  |  View Paper
We found that RANKL-dependent calcium Ca ) influx into osteoclast progenitors was significantly inhibited by MTX.
Journal of Bone and Mineral Metabolism  •  2015  |  View Paper
MTX treatment was associated with significantly decreased plasma calcium , bilirubin, alkaline phosphatase, aspartate aminotransferase and the total white cell count.
Immunology and cell biology  •  1994  |  View Paper
methotrexate caused more frequent (from the second week on) the appearance of more intense degenerative changes, and from … of cardiomyocytes, local increase of acid phosphatase activity from the second week on, falling activity of calcium and magnesium dependent ATPases from the fifth … in the sixth week of the experiment.
Materia medica Polona. Polish journal of medicine and pharmacy  •  1990  |  View Paper
Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1980  |  View Paper