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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Methotrexate and Calcium Supplement

Research Papers that Mention the Interaction

MTX inhibited keratinocyte growth, which was enhanced synergistically by calcium.
Journal of the American Academy of Dermatology  •  2015  |  View Paper
MTX … calcium ionophore-driven LTB4 generation from the neutrophils of asthmatics (358.9 +/- 39.5 pg/10(6) cells vs 240.1 +/- 29.1 pg/10(…, p < 0.05) and attenuated PHA-induced mononuclear DNA synthesis as shown by a reduction in 3H-thymidine uptake and propidium iodide staining.
Asian Pacific journal of allergy and immunology  •  1994  |  View Paper
Leucovorin calcium is given to cancer patients receiving high-dose methotrexate to retard the onset of serious side effects.
Patient counselling and health education  •  1982  |  View Paper
We found that RANKL-dependent calcium Ca ) influx into osteoclast progenitors was significantly inhibited by MTX.
Journal of Bone and Mineral Metabolism  •  2015  |  View Paper
The MTX (1 ng/ml)-induced increase in [Ca2+]i was partially inhibited by the omission of extracellular Ca2+ (Ca2+e) or the addition of verapamil, but not by adding nifedipine, omega-agatoxin IVA, omega-conotoxin GVIA and omega-conotoxin MVIIC.
Japanese journal of pharmacology  •  2001  |  View Paper
methotrexate caused more frequent (from the second week on) the appearance of more intense degenerative changes, and from … of cardiomyocytes, local increase of acid phosphatase activity from the second week on, falling activity of calcium and magnesium dependent ATPases from the fifth … in the sixth week of the experiment.
Materia medica Polona. Polish journal of medicine and pharmacy  •  1990  |  View Paper
Binding measurements with [3H]Methotrexate provide KD values of ca.
Biochemical and biophysical research communications  •  1984  |  View Paper