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Discover Supplement-Drug Interactions
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Last Updated: 4 months ago
drug:
Methotrexate
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“This effect was explained by inhibition of 2-oxoglutarate and isocitrate dehydrogenases by MTX.”
Effect of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzyme, 2-oxoglutarate and isocitrate dehydrogenases.“ MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate.”
Methotrexate: studies on cellular metabolism. II--Effects on mitochondrial oxidative metabolism and ion transport.“ MTX was able to inhibit state III respiration activated by ADP and to decrease the respiratory coefficient with the substrates alpha-ketoglutarate and glutamate; these effects became pronounced when mitochondria were pre-incubated with MTX for 10 min.”
“Double reciprocal plats indicate a competitive inhibition for alpha-ketoglutarate-glutamate by folic acid and methotrexate and a complex or mixed type for NAD-NADH site.”
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