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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Methotrexate
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“This effect was explained by inhibition of 2-oxoglutarate and isocitrate dehydrogenases by MTX.”
Effect of methotrexate (MTX) on NAD(P)+ dehydrogenases of HeLa cells: malic enzyme, 2‐oxoglutarate and isocitrate dehydrogenases“ MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate.”
Methotrexate: Studies on cellular metabolism. II—Effects on mitochondrial oxidative metabolism and ion transport“ MTX was able to inhibit state III respiration activated by ADP and to decrease the respiratory coefficient with the substrates alpha-ketoglutarate and glutamate; these effects became pronounced when mitochondria were pre-incubated with MTX for 10 min.”
“Double reciprocal plats indicate a competitive inhibition for alpha-ketoglutarate-glutamate by folic acid and methotrexate and a complex or mixed type for NAD-NADH site.”
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