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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Methotrexate and Alpha-Ketoglutarate

Research Papers that Mention the Interaction

This effect was explained by inhibition of 2-oxoglutarate and isocitrate dehydrogenases by MTX.
Cell biochemistry and function  •  1997  |  View Paper
MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate.
Cell biochemistry and function  •  1989  |  View Paper
MTX was able to inhibit state III respiration activated by ADP and to decrease the respiratory coefficient with the substrates alpha-ketoglutarate and glutamate; these effects became pronounced when mitochondria were pre-incubated with MTX for 10 min.
Cell biochemistry and function  •  1988  |  View Paper
Double reciprocal plats indicate a competitive inhibition for alpha-ketoglutarate-glutamate by folic acid and methotrexate and a complex or mixed type for NAD-NADH site.
Biochimica et biophysica acta  •  1976  |  View Paper